Influence of (11)C-choline PET/CT on the treatment planning for salvage radiation therapy in patients with biochemical recurrence of prostate cancer.

Souvatzoglou, M; Krause, BJ; Pürschel, A; Thamm, R; Schuster, T; Buck, AK; Zimmermann, F; Molls, M; Schwaiger, M; Geinitz, H

doi:10.1016/j.radonc.2011.05.005

journal article

Dokumenttyp:: Journal Article
Autor(en):: Souvatzoglou, M; Krause, BJ; Pürschel, A; Thamm, R; Schuster, T; Buck, AK; Zimmermann, F; Molls, M; Schwaiger, M; Geinitz, H
Titel:: Influence of (11)C-choline PET/CT on the treatment planning for salvage radiation therapy in patients with biochemical recurrence of prostate cancer.
Abstract:: The present study evaluates the incidence of (11)C-choline PET/CT positive findings in patients with recurrent prostate cancer referred for salvage radiotherapy (SRT) and the influence on the definition of the planning target volume (PTV).Thirty-seven patients treated with radical prostatectomy and referred to SRT to the prostatic fossa because of biochemical relapse, were analysed retrospectively. All patients underwent (11)C-choline PET/CT before radiotherapy. The influence of PET/CT on the extent of the PTV was analysed. The median total follow up after SRT was 51.2 months.11/37 (30%) patients had a positive finding in the (11)C-choline PET/CT, 5 (13%) outside of the prostatic fossa (iliac lymph nodes), implicating an extension of the PTV. Patients with positive (11)C-choline PET/CT had a significant higher PSA value than patients with no pathologic uptake (p=0.03). Overall, at the end of follow up 56% of the patients had a PSA <= 0.2ng/ml and 44% had a biochemical relapse of prostate cancer.(11)C-choline PET/CT detects abnormalities outside of the prostatic fossa in 13% of patients referred for SRT because of biochemical relapse after radical prostatectomy, affecting the extent of the PTV. Prospective studies need to be implemented to evaluate the benefit of SRT with a PTV based on (11)C-choline PET/CT.
Zeitschriftentitel:: Radiother Oncol
Jahr:: 2011
Band / Volume:: 99
Heft / Issue:: 2
Seitenangaben Beitrag:: 193-200
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.radonc.2011.05.005
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/21620494
Print-ISSN:: 0167-8140
TUM Einrichtung:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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