Interaction of biomechanics and metabolic activity in abdominal aortic aneurysm wall

The interplay of biomechanical stresses to subsequent histopathological response in the wall of abdominal aortic aneurysm (AAA) is poorly understood and investigated. Meanwhile individually acting forces can be calculated precisely by wall stress analyses as well as biologic activity of AAA wall can be studied in-vivo by 18F-fluorodeoxyglucose positron emission tomography. For better insights in stresstissue interactions and methodical reasons we studied therefore the correlation of metabolic activity with the results of computational wall stress analyses in two patients. Thereby, areas of highest metabolic activity were well correlated to regions with highest computational peak wall stress for these two patients. To proof these findings further analyses in 25 patients are planned and the results will be presented.     «

The interplay of biomechanical stresses to subsequent histopathological response in the wall of abdominal aortic aneurysm (AAA) is poorly understood and investigated. Meanwhile individually acting forces can be calculated precisely by wall stress analyses as well as biologic activity of AAA wall can be studied in-vivo by 18F-fluorodeoxyglucose positron emission tomography. For better insights in stresstissue interactions and methodical reasons we studied therefore the correlation of metabolic ac...     »