In this work we investigated the role of mig-6 and its relation to the EGFR receptors family in colon cancer and in glioblastoma. In the first part of the study, a negative correlation between HER3 (ErbB3) and mig-6 in primary colon cancer tumors as well as in colon cancer cell lines was shown. On the other hand, we demonstrated that HER3 could be considered as a target for colon cancer therapy, since HER3 expression was shown to confer poor prognosis in colon cancer patients. In line with this, In-vitro studies employing 4 different colon cancer cell lines revealed that blocking of HER3 either by using siRNA or blocking antibody resulted in an inhibition of proliferation, migration as well as of invasion and could induce apoptosis. In the second part of the study, we investigated the link between mig-6 adaptor protein and EGFRvIII. An interaction as well as an inverse correlation between these two proteins was shown.
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In this work we investigated the role of mig-6 and its relation to the EGFR receptors family in colon cancer and in glioblastoma. In the first part of the study, a negative correlation between HER3 (ErbB3) and mig-6 in primary colon cancer tumors as well as in colon cancer cell lines was shown. On the other hand, we demonstrated that HER3 could be considered as a target for colon cancer therapy, since HER3 expression was shown to confer poor prognosis in colon cancer patients. In line with this,...
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