Benutzer: Gast  Login
Dokumenttyp:
Comparative Study; Journal Article; nicht gelistet
Autor(en):
Krüger, S; Mottaghy, FM; Buck, AK; Maschke, S; Kley, H; Frechen, D; Wibmer, T; Reske, SN; Pauls, S
Titel:
Brain metastasis in lung cancer. Comparison of cerebral MRI and 18F-FDG-PET/CT for diagnosis in the initial staging.
Abstract:
FDG-PET/CT is increasingly used in staging of lung cancer as single "one stop shop" method. AIM, PATIENTS, METHODS: We prospectively included 104 neurological asymptomatic patients (65 years, 26% women) with primary diagnosis of lung cancer. In all patients PET/CT including cerebral imaging and cerebral MRI were performed.Diagnosis of brain metastases (BM) was made by PET/CT in 8 patients only (7.7%), by MRI in 22 (21.2%). In 80 patients both PET/CT and MRI showed no BM. In 6 patients (5.8%) BM were detectable on PET/CT as well as on MRI. Exclusive diagnosis of BM by MRI with negative finding on PET/CT was present in 16 patients (15.4%). 2 patients (1.9%) had findings typical for BM on PET/CT but were negative on MRI. With MRI overall 100 BM were detected, with PET/CT only 17 BM (p < 0.01). For the diagnosis of BM PET/CT showed a sensitivity of 27.3%, specificity of 97.6%, positive predictive value of 75% and negative predictive value of 83.3%. BM diameter on PET/CT and MRI were consistent in 43%, in 57% BM were measured larger on MRI.Compared to the gold standard of MRI for cerebral staging a considerable number of patients are falsely diagnosed as free from BM by PET/CT. MRI is more accurate than PET/CT for detecting multiple and smaller BM.In patients with a curative option MRI should be performed additionally to PET/CT for definitive exclusion of brain metastases.
Zeitschriftentitel:
Nuklearmedizin
Jahr:
2011
Band / Volume:
50
Heft / Issue:
3
Seitenangaben Beitrag:
101-6
Sprache:
eng
Volltext / DOI:
doi:10.3413/Nukmed-0338-10-07
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21165538
Print-ISSN:
0029-5566
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
 BibTeX