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- Title:
Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard.
- Document type:
- journal article
- Author(s):
- Issever, AS; Link, TM; Kentenich, M; Rogalla, P; Burghardt, AJ; Kazakia, GJ; Majumdar, S; Diederichs, G
- Abstract:
- The aim of our study was to perform trabecular bone structure analysis with images from 64- and 320-slice multidetector computed tomography (MDCT) and to compare these with high-resolution peripheral computed tomography (HR-pQCT).Twenty human cadaver distal forearm specimens were imaged on a 64- and 320-slice MDCT system at 120 kVp, 200 mA and 135 kVp, 400 mA (in-plane pixel size 234 microm; slice thickness 500 microm). HR-pQCT imaging was performed at an isotropic voxel size of 41 microm. Bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp) were computed.MDCT-derived BV/TV and Tb.Sp were highly correlated (r = 0.92-0.96, p< 0.0001) with the corresponding HR-pQCT parameters. Tb.Th was the only structure measure that did not yield any significant correlation.The 64- and 320-slice MDCT systems both perform equally well in depicting trabecular bone architecture. However, because of constrained resolutions accurate derivation of trabecular bone measures is limited to only a subset of microarchitectural parameters.
- Journal title abbreviation:
- Eur Radiol
- Year:
- 2010
- Journal volume:
- 20
- Journal issue:
- 2
- Pages contribution:
- 458-68
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/19711081
- Print-ISSN:
- 0938-7994
- TUM Institution:
- Röntgendiagnostik
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