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Titel:

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gratio, V; Beaufort, N; Seiz, L; Maier, J; Virca, GD; Debela, M; Grebenchtchikov, N; Magdolen, V; Darmoul, D
Abstract:
Certain serine proteases are considered to be signaling molecules that act through protease-activated receptors (PARs). Our recent studies have implicated PAR1 and PAR4 (thrombin receptors) and PAR2 (trypsin receptor) in human colon cancer growth. Here we analyzed the expression of KLK4, a member of the kallikrein-related peptidase (KLK) family of serine proteases and explored whether this member can activate PAR1 and PAR2 in human colon cancer cells. Immunohistochemistry showed KLK4 expression...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2010
Band / Volume:
176
Heft / Issue:
3
Seitenangaben Beitrag:
1452-61
Sprache:
eng
Volltext / DOI:
doi:10.2353/ajpath.2010.090523
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20056842
Print-ISSN:
0002-9440
TUM Einrichtung:
Frauenklinik und Poliklinik
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