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Title:

A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: A new approaches to neuroblastoma therapy (NANT) study.

Document type:
journal article
Author(s):
Russell, HV; Groshen, SG; Ara, T; Declerck, YA; Hawkins, R; Jackson, HA; Daldrup-Link, HE; Marachelian, A; Skerjanec, A; Park, JR; Katzenstein, H; Matthay, KK; Blaney, SM; Villablanca, JG
Abstract:
BACKGROUND: Zoledronic acid, a bisphosphonate, delays progression of bone metastases in adult malignancies. Bone is a common metastatic site of advanced neuroblastoma. We previously reported efficacy of zoledronic acid in a murine model of neuroblastoma bone invasion prompting this Phase I trial of zoledronic acid with cyclophosphamide in children with neuroblastoma and bone metastases. The primary objective was to determine recommended dosing of zoledronic acid for future trials. PROCEDURE: Esc...     »
Journal title abbreviation:
Pediatr Blood Cancer
Year:
2010
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21077182
Print-ISSN:
1545-5009
TUM Institution:
Röntgendiagnostik
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