Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses.

Sellner, J; Cepok, S; Kalluri, SR; Nestler, A; Kleiter, I; Kümpfel, T; Linker, R; Melms, A; Menge, T; Tumani, H; Paul, F; Hemmer, B; Berthele, A

doi:10.1016/j.neuint.2010.08.003

journal article

Titel:: Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Sellner, J; Cepok, S; Kalluri, SR; Nestler, A; Kleiter, I; Kümpfel, T; Linker, R; Melms, A; Menge, T; Tumani, H; Paul, F; Hemmer, B; Berthele, A
Abstract:: Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS). Serum samples of patients with AQP4 antibody positive CNS autoimmunity (n=52), relapsing-remitting MS (n=55) and controls including non-autoimmune neurological disorders and healthy individuals (n=56) were tested for IgG antibodies to herpes viruses 1-6 (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) using commercial ELISA kits. AQP4 antibody positive CNS autoimmunity cases most frequently had IgG responses to four viruses (38.5%), while presence of antibodies to three herpes viruses was most common in MS and controls (41.8% and 35.7%, respectively). Compared to MS, AQP4 positive cases had a significantly higher CMV seropositivity rate (P=0.003) and a lower prevalence of EBV antibodies (P=0.01). The analysis of immunoreactivity of samples above the diagnostic threshold revealed that in AQP4 positive CNS autoimmunity the IgG response to EBV (P<0.001) and VZV (P<0.01) was lower than in MS, whereas immununoreactivity to HSV-1 was higher than in controls (P<0.01). The distinct pattern of seroprevalence and immunoreactivity against herpes viruses in AQP4 positive CNS autoimmunity and MS provide further insights to the pathogenetical heterogeneity. Whether these findings reflect an epi-phenomenon of autoimmune disorders or indicate a disease-specific deregulated virus-host interaction needs to be examined in further studies.
Zeitschriftentitel:: Neurochem Int
Jahr:: 2010
Band / Volume:: 57
Heft / Issue:: 6
Seitenangaben Beitrag:: 662-7
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.neuint.2010.08.003
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/20705110
Print-ISSN:: 0197-0186
TUM Einrichtung:: Neurologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurologie (Prof. Hemmer)2010