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Titel:

Role of serum and glucocorticoid-regulated kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Rusai, K; Prokai, A; Szebeni, B; Fekete, A; Treszl, A; Vannay, A; Müller, V; Reusz, G; Heemann, U; Lutz, J; Tulassay, T; Szabo, AJ
Abstract:
Erythropoietin (EPO) protects the kidneys from ischemia/reperfusion (I/R) injury; however, the exact signalling mechanisms are not fully understood. The serum and glucocorticoid-regulated kinase 1 (SGK1) is an anti-apoptotic protein kinase regulated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway by cellular stimuli, hormones and growth factors. The objective of the present study was to examine the role of SGK1 in the renoprotective effects of EPO in renal I/R injury. In vitro, c...     »
Zeitschriftentitel:
Biochem Pharmacol
Jahr:
2010
Band / Volume:
79
Heft / Issue:
8
Seitenangaben Beitrag:
1173-81
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bcp.2009.11.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19961832
Print-ISSN:
0006-2952
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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