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Titel:

Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Buckley, SM; Ulloa-Montoya, F; Abts, D; Oostendorp, RA; Dzierzak, E; Ekker, SC; Verfaillie, CM
Abstract:
The microenvironment wherein hematopoietic stem cells (HSC) reside orchestrates HSC self-renewal vs. differentiation decisions. Stromal cells derived from ontogenically divergent hematopoietic microenvironments can support HSC in vitro and have been used to decipher factors that influence HSC fate decisions. Employing stromal cell lines derived from the aorta-gonad-mesonephros and embryonic liver, we aim to identify secreted factors that maintain/expand HSC in vitro.We cultured murine lineage an...     »
Zeitschriftentitel:
Exp Hematol
Jahr:
2011
Band / Volume:
39
Heft / Issue:
1
Seitenangaben Beitrag:
114-123.e1-5
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.exphem.2010.09.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20933051
Print-ISSN:
0301-472X
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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