User: Guest  Login
More Searchfields
Simple search
Title:

SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, Non-U.S. Gov't
Author(s):
Schüler, S; Diersch, S; Hamacher, R; Schmid, RM; Saur, D; Schneider, G
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis and no effective conservative therapy exists. Although the F-box protein S-phase kinase associated protein 2 (SKP2) is highly expressed and regulates cell cycle progression in PDAC, alternative SKP2 functions in PDAC are unknown. Using RNA interference we now demonstrate that SKP2 confers resistance of a subset of PDAC cell lines towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not the...     »
Journal title abbreviation:
Int J Oncol
Year:
2011
Journal volume:
38
Journal issue:
1
Pages contribution:
219-25
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21109943
Print-ISSN:
1019-6439
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
 BibTeX