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Titel:

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lesina, M; Kurkowski, MU; Ludes, K; Rose-John, S; Treiber, M; Klöppel, G; Yoshimura, A; Reindl, W; Sipos, B; Akira, S; Schmid, RM; Algul, H
Abstract:
Physiological levels of Kras(G12D) are sufficient to induce pancreatic intraepithelial neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we establish that, in addition to oncogenic Kras(G12D), IL-6 transsignaling-dependent activation of Stat3/Socs3 is required to promote PanIN progression and pancreatic ductal adenocarcinoma (PDAC). Myeloid compartment induces Stat3 activation by secreting IL-6; consequently, IL-6 transsignaling activates Stat3 in the pancreas...     »
Zeitschriftentitel:
Cancer Cell
Jahr:
2011
Band / Volume:
19
Heft / Issue:
4
Seitenangaben Beitrag:
456-69
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ccr.2011.03.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21481788
Print-ISSN:
1535-6108
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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