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Titel:

Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, Non-U.S. Gov't
Autor(en):
Lian, F; Xing, X; Yuan, G; Schafer, C; Rauser, S; Walch, A; Röcken, C; Ebeling, M; Wright, MB; Schmid, RM; Ebert, MP; Burgermeister, E
Abstract:
Bile acids from duodenogastric reflux promote inflammation and increase the risk for gastro-oesophageal cancers. FXR (farnesoid X receptor/NR1H4) is a transcription factor regulated by bile acids such as CDCA (chenodeoxycholic acid). FXR protects the liver and the intestinal tract against bile acid overload; however, a functional role for FXR in the stomach has not been described. We detected FXR expression in the normal human stomach and in GC (gastric cancer). FXR mRNA and protein were also p...     »
Zeitschriftentitel:
Biochem J
Jahr:
2011
Band / Volume:
438
Heft / Issue:
2
Seitenangaben Beitrag:
315-23
Sprache:
eng
Volltext / DOI:
doi:10.1042/BJ20102096
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21619550
Print-ISSN:
0264-6021
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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