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Titel:

SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, Non-U.S. Gov't
Autor(en):
Schüler, S; Diersch, S; Hamacher, R; Schmid, RM; Saur, D; Schneider, G
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis and no effective conservative therapy exists. Although the F-box protein S-phase kinase associated protein 2 (SKP2) is highly expressed and regulates cell cycle progression in PDAC, alternative SKP2 functions in PDAC are unknown. Using RNA interference we now demonstrate that SKP2 confers resistance of a subset of PDAC cell lines towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not the...     »
Zeitschriftentitel:
Int J Oncol
Jahr:
2011
Band / Volume:
38
Heft / Issue:
1
Seitenangaben Beitrag:
219-25
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21109943
Print-ISSN:
1019-6439
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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