Genome-wide association study of PR interval.

Pfeufer, A; van Noord, C; Marciante, KD; Arking, DE; Larson, MG; Smith, AV; Tarasov, KV; Muller, M; Sotoodehnia, N; Sinner, MF; Verwoert, GC; Li, M; Kao, WH; Köttgen, A; Coresh, J; Bis, JC; Psaty, BM; Rice, K; Rotter, JI; Rivadeneira, F; Hofman, A; Kors, JA; Stricker, BH; Uitterlinden, AG; van Duijn, CM; Beckmann, BM; Sauter, W; Gieger, C; Lubitz, SA; Newton-Cheh, C; Wang, TJ; Magnani, JW; Schnabel, RB; Chung, MK; Barnard, J; Smith, JD; Van Wagoner, DR; Vasan, RS; Aspelund, T; Eiriksdottir, G; Harris, TB; Launer, LJ; Najjar, SS; Lakatta, E; Schlessinger, D; Uda, M; Abecasis, GR; Müller-Myhsok, B; Ehret, GB; Boerwinkle, E; Chakravarti, A; Soliman, EZ; Lunetta, KL; Perz, S; Wichmann, HE; Meitinger, T; Levy, D; Gudnason, V; Ellinor, PT; Sanna, S; Kääb, S; Witteman, JC; Alonso, A; Benjamin, EJ; Heckbert, SR

doi:10.1038/ng.517

Benutzer: Gast

journal article

Titel:: Genome-wide association study of PR interval.
Dokumenttyp:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Article
Autor(en):: Pfeufer, A; van Noord, C; Marciante, KD; Arking, DE; Larson, MG; Smith, AV; Tarasov, KV; Muller, M; Sotoodehnia, N; Sinner, MF; Verwoert, GC; Li, M; Kao, WH; Köttgen, A; Coresh, J; Bis, JC; Psaty, BM; Rice, K; Rotter, JI; Rivadeneira, F; Hofman, A; Kors, JA; Stricker, BH; Uitterlinden, AG; van Duijn, CM; Beckmann, BM; Sauter, W; Gieger, C; Lubitz, SA; Newton-Cheh, C; Wang, TJ; Magnani, JW; Schnabel, RB; Chung, MK; Barnard, J; Smith, JD; Van Wagoner, DR; Vasan, RS; Aspelund, T; Eiriksdottir, G; Harris, TB; Launer, LJ; Najjar, SS; Lakatta, E; Schlessinger, D; Uda, M; Abecasis, GR; Müller-Myhsok, B; Ehret, GB; Boerwinkle, E; Chakravarti, A; Soliman, EZ; Lunetta, KL; Perz, S; Wichmann, HE; Meitinger, T; Levy, D; Gudnason, V; Ellinor, PT; Sanna, S; Kääb, S; Witteman, JC; Alonso, A; Benjamin, EJ; Heckbert, SR «
Pfeufer, A; van Noord, C; Marciante, KD; Arking, DE; Larson, MG; Smith, AV; Tarasov, KV; Muller, M; Sotoodehnia, N; Sinner, MF; Verwoert, GC; Li, M; Kao, WH; Köttgen, A; Coresh, J; Bis, JC; Psaty, BM; Rice, K; Rotter, JI; Rivadeneira, F; Hofman, A; Kors, JA; Stricker, BH; Uitterlinden, AG; van Duijn, CM; Beckmann, BM; Sauter, W; Gieger, C; Lubitz, SA; Newton-Cheh, C; Wang, TJ; Magnani, JW; Schnabel, RB; Chung, MK; Barnard, J; Smith, JD; Van Wagoner, DR; Vasan, RS; Aspelund, T; Eiriksdottir, G; H... »
Abstract:: The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.
Zeitschriftentitel:: Nat Genet
Jahr:: 2010
Band / Volume:: 42
Heft / Issue:: 2
Seitenangaben Beitrag:: 153-9
Sprache:: eng
Volltext / DOI:: doi:10.1038/ng.517
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/20062060
Print-ISSN:: 1061-4036
TUM Einrichtung:: Institut für Humangenetik
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