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Title:

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ohler, A; Debela, M; Wagner, S; Magdolen, V; Becker-Pauly, C
Abstract:
The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of human epidermis indicating distinct physiological functions, supported by effects on cultured keratinocytes. Meprin beta induces a dramatic change in cell morphology and a significant reduction in cell number, whereas in vitro evidence suggests a role for meprin alpha in basal keratinocyte proliferation. Meprins are secreted as zymogens tha...     »
Journal title abbreviation:
Biol Chem
Year:
2010
Journal volume:
391
Journal issue:
4
Pages contribution:
455-60
Language:
eng
Fulltext / DOI:
doi:10.1515/BC.2010.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20128684
Print-ISSN:
1431-6730
TUM Institution:
Frauenklinik und Poliklinik
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