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Title:

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Document type:
Journal Article; Review
Author(s):
Mengele, K; Napieralski, R; Magdolen, V; Reuning, U; Gkazepis, A; Sweep, F; Brünner, N; Foekens, J; Harbeck, N; Schmitt, M
Abstract:
In cancer, the serine protease urokinase-type plasminogen activator, its inhibitor (plasminogen activator inhibitor type-1) and the receptor (CD87), among other proteolytic factors, are involved in tumor cell dissemination and turnover of the extracellular matrix. Unsurprisingly, a battery of very uniform data, amassed since the end of the 1990s, has put these members of the plasminogen activation system into the forefront of prognostic/predictive cancer biomarkers relevant to predict the clinic...     »
Journal title abbreviation:
Expert Rev Mol Diagn
Year:
2010
Journal volume:
10
Journal issue:
7
Pages contribution:
947-62
Language:
eng
Fulltext / DOI:
doi:10.1586/erm.10.73
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20964613
Print-ISSN:
1473-7159
TUM Institution:
Frauenklinik und Poliklinik
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