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Title:

Bioactivation of dermal scaffolds with a non-viral copolymer-protected gene vector.

Document type:
Journal Article; Article
Author(s):
Reckhenrich, AK; Hopfner, U; Krötz, F; Zhang, Z; Koch, C; Kremer, M; Machens, HG; Plank, C; Egana, JT
Abstract:
The use of scaffolds in skin tissue engineering is accompanied with low regeneration rates and high risk of infection. In this study, we activated an FDA-approved collagen scaffold for dermal regeneration by incorporation of copolymer-protected gene vectors (COPROGs) to induce a temporary release of VEGF. In vitro results show that the presence of COPROGs did not affect the distribution, attachment, proliferation and viability of cells in the scaffold. A transient release of VEGF was observed fo...     »
Journal title abbreviation:
Biomaterials
Year:
2011
Journal volume:
32
Journal issue:
7
Pages contribution:
1996-2003
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2010.11.022
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21159378
Print-ISSN:
0142-9612
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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