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Titel:

Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Thiermann, H; Eyer, F; Felgenhauer, N; Pfab, R; Zilker, T; Eyer, P; Worek, F
Abstract:
Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated. An obidoxime plasma level in the range of 10-20 microM was estimated as appropriate. The achievement of this target was assessed in 34 severely OP-poisoned patients.After admission to the intensive care unit (ICU) the...     »
Zeitschriftentitel:
Toxicol Lett
Jahr:
2010
Band / Volume:
197
Heft / Issue:
3
Seitenangaben Beitrag:
236-42
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.toxlet.2010.06.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20542100
Print-ISSN:
0378-4274
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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