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Titel:

PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer.

Dokumenttyp:
Journal Article; Article
Autor(en):
Su, Y; Loos, M; Giese, N; Hines, OJ; Diebold, I; Gorlach, A; Metzen, E; Pastorekova, S; Friess, H; Büchler, P
Abstract:
Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1?. The effects of PHD3 in tumour growth are largely unknown.PHD3 expression was analysed in human pancreatic cancer tissues and cancer cell lines by real-time quantitative PCR and immunohistochemistry. PHD3 overexpression was established by stable transfection and downregulation by short interfering RNA technology. VEGF was...     »
Zeitschriftentitel:
Br J Cancer
Jahr:
2010
Band / Volume:
103
Heft / Issue:
10
Seitenangaben Beitrag:
1571-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.bjc.6605936
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20978507
Print-ISSN:
0007-0920
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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