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Titel:

A randomized multicenter phase II study comparing capecitabine with irinotecan or cisplatin in metastatic adenocarcinoma of the stomach or esophagogastric junction.

Dokumenttyp:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Autor(en):
Moehler, M; Kanzler, S; Geissler, M; Raedle, J; Ebert, MP; Daum, S; Flieger, D; Seufferlein, T; Galle, PR; Hoehler, T
Abstract:
The combination of irinotecan with 5-fluorouracil demonstrates efficacy with tolerable safety in the first-line treatment of metastatic gastroesophageal cancer (mGC). This randomized phase II trial compared for the first time capecitabine with irinotecan or cisplatin in this setting.Patients were randomly assigned to receive 3-week cycles of capecitabine 1000 mg/m(2), twice daily for 14 days, with on day 1 either irinotecan 250 mg/m(2) (XI) or cisplatin 80 mg/m(2) (XP). The primary end point was...     »
Zeitschriftentitel:
Ann Oncol
Jahr:
2010
Band / Volume:
21
Heft / Issue:
1
Seitenangaben Beitrag:
71-7
Sprache:
eng
Volltext / DOI:
doi:10.1093/annonc/mdp269
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19605504
Print-ISSN:
0923-7534
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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