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Title:

Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ingold, B; Simon, E; Ungethüm, U; Kuban, RJ; Müller, BM; Lupp, A; Neumann, U; Ebert, MP; Denkert, C; Weichert, W; Schulz, S; Röcken, C
Abstract:
G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas.Differential expression of GPCRs in three node positive vs. three node negative intestinal type gastric carcinomas was analyzed by gene array technology. The candidate genes CXCL12 and its receptor CXCR4 were validated by real-time reverse-transcription polymerase chain reaction in an independent set of 3...     »
Journal title abbreviation:
PLoS ONE
Year:
2010
Journal volume:
5
Journal issue:
4
Pages contribution:
e10087
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0010087
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20386750
Print-ISSN:
1932-6203
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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