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Titel:

ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non-Small Cell Lung Cancer.

Dokumenttyp:
Journal Article
Autor(en):
Baumgart, A; Seidl, S; Vlachou, P; Michel, L; Mitova, N; Schatz, N; Specht, K; Koch, I; Schuster, T; Grundler, R; Kremer, M; Fend, F; Siveke, JT; Peschel, C; Duyster, J; Dechow, T
Abstract:
Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non-small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies are used, the prognosis of NSCLC remains poor. ADAM17 induces activation of the EGFR through ligand cleavage. However, we show that inhibition or knockdown of ADAM17 markedly reduces tumorigenesis and survival to a large part independently from EGFR ligand shedding in NSCLC cells. These findings strongly indicate additional oncogenic mecha...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2010
Band / Volume:
70
Heft / Issue:
13
Seitenangaben Beitrag:
5368-5378
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-09-3763
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20551051
Print-ISSN:
0008-5472
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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