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Title:

Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Vallon, M; Rohde, F; Janssen, KP; Essler, M
Abstract:
Tumor endothelial marker (TEM) 5 is an adhesion G-protein-coupled receptor upregulated in endothelial cells during tumor and physiologic angiogenesis. So far, the mechanisms leading to upregulation of TEM5 and its function during angiogenesis have not been identified. Here, we report that TEM5 expression in endothelial cells is induced during capillary-like network formation on Matrigel, during capillary morphogenesis in a three-dimensional collagen I matrix, and upon confluence on a two-dimensi...     »
Journal title abbreviation:
Exp Cell Res
Year:
2010
Journal volume:
316
Journal issue:
3
Pages contribution:
412-21
Language:
eng
Fulltext / DOI:
doi:10.1016/j.yexcr.2009.10.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19853600
Print-ISSN:
0014-4827
TUM Institution:
Chirurgische Klinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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