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Title:

Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schelter, F; Gerg, M; Halbgewachs, B; Schaten, S; Gorlach, A; Schrötzlmair, F; Kruger, A
Abstract:
During tumor progression, malignant cells must repeatedly survive microenvironmental stress. Hypoxia-inducible factor-1 (HIF-1) signaling has emerged as one major pathway allowing cellular adaptation to stress. Recent findings led to the hypothesis that HIF-1alpha may enhance the metastatic potential of tumor cells by a survival-independent mechanism. So far it has not been shown that HIF-1alpha also directly regulates invasive processes during metastasis in addition to conferring a survival adv...     »
Journal title abbreviation:
J Biol Chem
Year:
2010
Journal volume:
285
Journal issue:
34
Pages contribution:
26182-9
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M110.140608
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20566631
Print-ISSN:
0021-9258
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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