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- Titel:
Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetes.
- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- von Eynatten, M; Baumann, M; Heemann, U; Zdunek, D; Hess, G; Nawroth, PP; Bierhaus, A; Humpert, PM
- Abstract:
- BACKGROUND: Urinary liver-type fatty acid binding protein (L-FABP) and kidney injury molecule (KIM)-1, novel urinary biomarkers of renal tubulointerstitial function, have previously been associated with acute ischaemic kidney injury. We studied the clinical significance of urinary L-FABP, KIM-1 and N-acetyl-beta-glucosaminidase (NAG) as potential markers of renal function and chronic ischaemic injury in patients with diabetic nephropathy. MATERIAL AND METHODS: A total of 130 type 2 diabetes patients with early diabetic nephropathy and 40 healthy controls were studied. Urinary L-FABP, KIM-1, NAG, albumin excretion rate (AER) and creatinine clearance were obtained from 24-h urine samples, and correlated with measures of red blood cell count, renal function and metabolic control. RESULTS: Urinary L-FABP was significantly increased in diabetes patients compared with healthy controls [8.1 (interquartile 0.6-11.6) vs. 2.4 (0.5-3.6) microg/g creatinine, P < 0.001] and correlated with AER (r = 0.276, P = 0.002), creatinine clearance (r = -0.189, P = 0.033) and haemoglobin levels (r = -0.190, P = 0.030). In multivariable linear regression analysis, haemoglobin (beta = -0.247, P = 0.015) and AER (beta = 0.198, P = 0.046) were significant predictors of urinary L-FABP. Prevalent anaemia was independently associated with a 6-fold risk for increased tubulointerstitial kidney damage (upper vs. lower two L-FABP tertiles: OR, 6.06; 95% CI: 1.65-22.23; P = 0.007). Urinary KIM-1 was not significantly associated with kidney function, AER, or measures of red blood cell count while urinary NAG was associated with parameters of glucose control and renal function. CONCLUSIONS: Different urinary biomarkers may reflect distinct pathophysiological mechanisms of tubulointerstitial damage in early diabetic nephropathy: Urinary L-FABP could be a novel biomarker for chronic intrarenal ischaemia.
- Zeitschriftentitel:
- Eur J Clin Invest
- Jahr:
- 2010
- Band / Volume:
- 40
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 95-102
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1111/j.1365-2362.2009.02220.x
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/19912308
- Print-ISSN:
- 0014-2972
- TUM Einrichtung:
- Fachgebiet Nephrologie (Prof. Heemann)
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