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Title:

Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury.

Document type:
Journal Article; Article
Author(s):
Rusai, K; Sollinger, D; Baumann, M; Wagner, B; Strobl, M; Schmaderer, C; Roos, M; Kirschning, C; Heemann, U; Lutz, J
Abstract:
Toll-like receptors (TLRs) are an evolutionarily conserved family of cell membrane receptors that are part of the innate immunity system playing an important role as a first response to tissue injury. TLR2 and TLR4 are constitutively expressed on renal epithelium, and their expression is enhanced following renal ischemia/reperfusion (I/R) injury. Genetic deletion of either TLR2 or TLR4 protects from renal I/R injury. However, it is not known whether deletion of both combined protects the kidney...     »
Journal title abbreviation:
Pediatr Nephrol
Year:
2010
Journal volume:
25
Journal issue:
5
Pages contribution:
853-60
Language:
eng
Fulltext / DOI:
doi:10.1007/s00467-009-1422-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20130923
Print-ISSN:
0931-041X
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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