Benutzer: Gast  Login
Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Kunert, Christof; Skurk, Thomas; Frank, Oliver; Lang, Roman; Hauner, Hans; Hofmann, Thomas 
Titel:
Development and application of a stable isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers 
Abstract:
N-(1-Methyl-4-oxoimidazolidin-2-ylidene) alpha-amino acids were recently identified in roasted meat as so far unknown advanced glycation end products (AGEs) of creatinine. For the first time, this paper reports on the preparation of (13)C-labeled twin molecules of six N-(1-methyl-4-oxoimidazolidin-2-ylidene) alpha-amino acids and the development of a stable isotope dilution analysis (SIDA) for their simultaneous quantitation in meat, plasma, and urine samples by means of HPLC-MS/MS. Method valid...    »
 
Zeitschriftentitel:
Analytical Chemistry 
Jahr:
2013 
Band / Volume:
85 
Heft / Issue:
Seitenangaben Beitrag:
2961--2969 
Print-ISSN:
0003-2700