User: Guest  Login
Document type:
Zeitschriftenaufsatz 
Author(s):
Kunert, Christof; Skurk, Thomas; Frank, Oliver; Lang, Roman; Hauner, Hans; Hofmann, Thomas 
Title:
Development and application of a stable isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers 
Abstract:
N-(1-Methyl-4-oxoimidazolidin-2-ylidene) alpha-amino acids were recently identified in roasted meat as so far unknown advanced glycation end products (AGEs) of creatinine. For the first time, this paper reports on the preparation of (13)C-labeled twin molecules of six N-(1-methyl-4-oxoimidazolidin-2-ylidene) alpha-amino acids and the development of a stable isotope dilution analysis (SIDA) for their simultaneous quantitation in meat, plasma, and urine samples by means of HPLC-MS/MS. Method valid...    »
 
Journal title:
Analytical Chemistry 
Year:
2013 
Journal volume:
85 
Journal issue:
Pages contribution:
2961--2969 
Fulltext / DOI:
Print-ISSN:
0003-2700