Mucin-Inspired Lubrication on Hydrophobic Surfaces

Mucin-inspired lubrication on hydrophobic surfaces. By: Kasdorf, Benjamin Tillmann; Weber, Florian; Petrou, Georgia; et al. Biomacromolecules Published: 2017-Jun-21 (Epub 2017 Jun 21) Context Sensitive Links Close AbstractClose Abstract In the human body, high molecular weight glycoproteins called mucins play a key role in protecting epithelial surfaces against pathogenic attack, controlling the passage of molecules towards the tissue and enabling boundary lubrication with very low friction coefficients. However, neither the molecular mechanisms nor the chemical motifs of those biomacromolecules involved in these fundamental processes are fully understood. Thus, identifying the key features that render biomacromolecules such as mucins outstanding boundary lubricants could set the stage for creating versatile artificial superlubricants. We here demonstrate the importance of the hydrophobic terminal peptide domains of porcine gastric mucin (MUC5AC) and human salivary mucin (MUC5B) in the processes of adsorbing to and lubricating a hydrophobic PDMS surface. Tryptic digestion of those mucins results in removal of those terminal domains which is accompanied by a loss of lubricity as well as surface adsorption. We show that this loss can in part be compensated by attaching hydrophobic phenyl groups to the glycosylated central part of the mucin macromolecule. Furthermore, we demonstrate that the simple biopolysaccharide dextran can be functionalized with hydrophobic groups which confers efficient surface adsorption and good lubricity on PDMS to the polysaccharide.      «

Mucin-inspired lubrication on hydrophobic surfaces. By: Kasdorf, Benjamin Tillmann; Weber, Florian; Petrou, Georgia; et al. Biomacromolecules Published: 2017-Jun-21 (Epub 2017 Jun 21) Context Sensitive Links Close AbstractClose Abstract In the human body, high molecular weight glycoproteins called mucins play a key role in protecting epithelial surfaces against pathogenic attack, controlling the passage of molecules towards the tissue and enabling boundary lubrication with very low...     »