Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall.

Reeps, C; Pelisek, J; Seidl, S; Schuster, T; Zimmermann, A; Kuehnl, A; Eckstein, HH

doi:10.1159/000228900

journal article

Title:: Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall.
Document type:: Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Reeps, C; Pelisek, J; Seidl, S; Schuster, T; Zimmermann, A; Kuehnl, A; Eckstein, HH
Abstract:: OBJECTIVES: Abdominal aortic aneurysm (AAA) wall is characterized by degradation of extracellular matrix through matrix metalloproteinases (MMPs), chronic inflammatory cell infiltration and extensive neovascularization. So far, MMP expression within AAA wall in association with infiltrates and neovascularization has not yet been studied. METHODS: Vessel walls of 15 AAA patients and 8 organ donors were analyzed by immunohistochemistry for expression of various MMPs (MMP-1, -2, -3, -7, -8, -9, -12 and -13) in all cells located within the AAAs and correlated with infiltrates and neovascularization. RESULTS: Luminal endothelial cells (ECs) were positive for MMP-1, -3 and -9, ECs of mature neovessels were furthermore positive for MMP-2. Immature neovessels expressed all MMPs tested except for MMP-13. Aortic medial smooth muscle cells (SMCs) expressed MMP-1, -2, -3 and -9, SMCs of mature neovessels, only MMP-1, -3 and -9. Inflammatory infiltrates expressed all MMPs tested except for MMP-2, macrophages expressed all MMPs. Infiltrates were composed mainly of B cells (58.5 +/- 10.9%) and T lymphocytes (26.3 +/- 9.5%). Furthermore, significant inverse correlations were found between the amounts of inflammatory cells, neovessels and collagen/elastin content of the aortic vessel wall (r = +0.806/p < 0.001, r = -0.650/p = 0.012, r = -0.63/p < 0.015; respectively). CONCLUSION: Inflammatory infiltrates and invading neovessels are relevant sources of MMPs in the AAA wall and may substantially contribute to aneurysm wall instability.
Journal title abbreviation:: Pathobiology
Year:: 2009
Journal volume:: 76
Journal issue:: 5
Pages contribution:: 243-52
Language:: eng
Fulltext / DOI:: doi:10.1159/000228900
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19816084
Print-ISSN:: 1015-2008
TUM Institution:: Fachgebiet Gefäßchirurgie (Prof. Eckstein); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2009

mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Institut für Allgemeine Pathologie und Pathologische Anatomie

mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Institut für Medizinische Statistik und Epidemiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie (Prof. Eckstein)2009

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2009