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Title:

Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gierse, Martin; Nagel, Luca; Keim, Michael; Lucas, Sebastian; Speidel, Tobias; Lobmeyer, Tobias; Winter, Gordon; Josten, Felix; Karaali, Senay; Fellermann, Maximilian; Scheuer, Jochen; Müller, Christoph; van Heijster, Frits; Skinner, Jason; Löffler, Jessica; Parker, Anna; Handwerker, Jonas; Marshall, Alastair; Salhov, Alon; El-Kassem, Bilal; Vassiliou, Christophoros; Blanchard, John W; Picazo-Frutos, Román; Eills, James; Barth, Holger; Jelezko, Fedor; Rasche, Volker; Schilling, Franz; Schwartz,...     »
Abstract:
We present a versatile method for the preparation of hyperpolarized [1-13C]fumarate as a contrast agent for preclinical in vivo MRI, using parahydrogen-induced polarization (PHIP). To benchmark this process, we compared a prototype PHIP polarizer to a state-of-the-art dissolution dynamic nuclear polarization (d-DNP) system. We found comparable polarization, volume, and concentration levels of the prepared solutions, while the preparation effort is significantly lower for the PHIP process, which...     »
Journal title abbreviation:
J Am Chem Soc
Year:
2023
Journal volume:
145
Journal issue:
10
Pages contribution:
5960-5969
Fulltext / DOI:
doi:10.1021/jacs.2c13830
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36857421
Print-ISSN:
0002-7863
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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