Oncological Outcome and Prognostic Factors of Surgery for Soft Tissue Sarcoma After Neoadjuvant or Adjuvant Radiation Therapy: A Retrospective Analysis over 15 Years.

Muehlhofer, Heinrich M L; Schlossmacher, Benjamin; Lenze, Ulrich; Lenze, Florian; Burgkart, Rainer; Gersing, Alexandra S; Peeken, Jan C; Combs, Stephanie E; VON Eisenhart-Rothe, Ruediger; Knebel, Carolin

doi:10.21873/anticanres.14784

journal article

Title:: Oncological Outcome and Prognostic Factors of Surgery for Soft Tissue Sarcoma After Neoadjuvant or Adjuvant Radiation Therapy: A Retrospective Analysis over 15 Years.
Document type:: Journal Article
Author(s):: Muehlhofer, Heinrich M L; Schlossmacher, Benjamin; Lenze, Ulrich; Lenze, Florian; Burgkart, Rainer; Gersing, Alexandra S; Peeken, Jan C; Combs, Stephanie E; VON Eisenhart-Rothe, Ruediger; Knebel, Carolin
Abstract:: BACKGROUND/AIM: Surgical resection for soft tissue sarcomas (STSs) is the gold standard for a curative oncologic therapy in combination with neoadjuvant or adjuvant radiation therapy (NRT/ART). The aim of this study was to determine prognostic factors influencing the survival of patients with STS undergoing NRT or ART considering various parameters in a retrospective, single-centre analysis over 15 years. PATIENTS AND METHODS: We included 119 patients (male 59) and the median follow-up period was 69 months (4-197). The patients received NRT (n=64) or ART (n=55). We recorded the histopathologic subtype of STS, tumour grade, localization, tumour margins, complications, survival, local recurrence, and metastases. Survival analysis was performed using the Kaplan-Meier method. RESULTS: The overall survival rate was 68.9% at 5 years. The localization (epifascial/subfascial), resection margin and type of radiation therapy (NRT/ART) had no significant impact on survival. Tumour grade, tumour size, local recurrence and metastases were significantly correlated with patient survival (p<0.05). Local recurrence was significantly higher in patients with ART (p=0.044). CONCLUSION: Tumour grade and tumour size were independently associated with disease-specific survival, and patients with local recurrence and metastases had lower survival rates.
Journal title abbreviation:: Anticancer Res
Year:: 2021
Journal volume:: 41
Journal issue:: 1
Pages contribution:: 359-368
Fulltext / DOI:: doi:10.21873/anticanres.14784
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/33419832
Print-ISSN:: 0250-7005
TUM Institution:: Institut für Diagnostische und Interventionelle Radiologie; Klinik und Poliklinik für Orthopädie und Sportorthopädie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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