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Title:

The neuropathology of fatal encephalomyelitis in human Borna virus infection.

Document type:
Journal Article
Author(s):
Liesche, Friederike; Ruf, Viktoria; Zoubaa, Saida; Kaletka, Gwendolyn; Rosati, Marco; Rubbenstroth, Dennis; Herden, Christiane; Goehring, Lutz; Wunderlich, Silke; Wachter, Miguel Frederic; Rieder, Georg; Lichtmannegger, Ines; Permanetter, Willibald; Heckmann, Josef G; Angstwurm, Klemens; Neumann, Bernhard; Märkl, Bruno; Haschka, Stefan; Niller, Hans-Helmut; Schmidt, Barbara; Jantsch, Jonathan; Brochhausen, Christoph; Schlottau, Kore; Ebinger, Arnt; Hemmer, Bernhard; Riemenschneider, Markus J; He...     »
Abstract:
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest-Degen inclusion bodies. While the comp...     »
Journal title abbreviation:
Acta Neuropathol (Berl)
Year:
2019
Journal volume:
138
Journal issue:
4
Pages contribution:
653-665
Fulltext / DOI:
doi:10.1007/s00401-019-02047-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31346692
Print-ISSN:
0001-6322
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Neurologische Klinik und Poliklinik
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