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Title:

A Continuously Infused Microfluidic Radioassay System for the Characterization of Cellular Pharmacokinetics.

Document type:
Journal Article
Author(s):
Liu, Zhen; Jian, Ziying; Wang, Qian; Cheng, Tao; Feuerecker, Benedikt; Schwaiger, Markus; Huang, Sung-Cheng; Ziegler, Sibylle I; Shi, Kuangyu
Abstract:
Measurement of cellular tracer uptake is widely applied to learn the physiologic status of cells and their interactions with imaging agents and pharmaceuticals. In-culture measurements have the advantage of less stress to cells. However, the tracer solution still needs to be loaded, unloaded, and purged from the cell culture during the measurements. Here, we propose a continuously infused microfluidic radioassay (CIMR) system for continuous in-culture measurement of cellular uptake. The system w...     »
Journal title abbreviation:
J Nucl Med
Year:
2016
Journal volume:
57
Journal issue:
10
Pages contribution:
1548-1555
Language:
eng
Fulltext / DOI:
doi:10.2967/jnumed.115.169151
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27363838
Print-ISSN:
0161-5505
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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