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Titel:

Diverse metabolic response of cancer cells treated with a 213Bi-anti-EGFR-immunoconjugate.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Feuerecker, Benedikt; Biechl, Philipp; Seidl, Christof; Bruchertseifer, Frank; Morgenstern, Alfred; Schwaiger, Markus; Eisenreich, Wolfgang
Abstract:
Evaluation of treatment response is among the major challenges in modern oncology. We herein used a monoclonal antibody targeting the EGF receptor (EGFR) labelled with the alpha emitter 213Bi (213Bi-anti-EGFR-MAb). EJ28Luc (bladder) and LN18 (glioma) cancer cells, both overexpressing EGFR, were incubated for 3 h with the radioimmunoconjugate. To assess the responses in the core carbon metabolism upon this treatment, these cancer cell lines were subsequently cultivated for 18 h in the presence of...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2021
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-021-84421-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33737524
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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