Despite its importance, shelf life of intermediates and finals is often neglected in capacity planning models in the bio-pharmaceutical industry. In particular, the process and bill of material dependent shelf life, which occurs in the production process of in-vitro diagnostic test kits has not yet been investigated. Therefore, this thesis presents a model that reflects the multi-stage and multi-product production process of diagnostic test kits and considers and optimises the bill of material dependent shelf life. To solve industry related problems a decomposition approach and a rolling horizon approach are introduced, which succeed in solving large-scale problems. From the results of several implemented case studies insights and general scheduling rules for shelf life optimized production plans can be derived.     «

Despite its importance, shelf life of intermediates and finals is often neglected in capacity planning models in the bio-pharmaceutical industry. In particular, the process and bill of material dependent shelf life, which occurs in the production process of in-vitro diagnostic test kits has not yet been investigated. Therefore, this thesis presents a model that reflects the multi-stage and multi-product production process of diagnostic test kits and considers and optimises the bill of material d...     »