Gender dependent rate of metabolism of the opioid receptor-PET ligand [18F]fluoroethyldiprenorphine.

Henriksen, G; Spilker, ME; Sprenger, T; Hauser, AI; Platzer, S; Boecker, H; Toelle, TR; Schwaiger, M; Wester, HJ

journal article

Titel:: Gender dependent rate of metabolism of the opioid receptor-PET ligand [18F]fluoroethyldiprenorphine.
Dokumenttyp:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Henriksen, G; Spilker, ME; Sprenger, T; Hauser, AI; Platzer, S; Boecker, H; Toelle, TR; Schwaiger, M; Wester, HJ
Abstract:: AIM: The morphinane-derivate 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyldiprenorphine ([(18)F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET). Correction for plasma metabolites of the arterial input function is necessary for quantitative measurements of [(18)F]FDPN binding. A study was undertaken to investigate if there are gender dependent differences in the rate of metabolism of [(18)F]FDPN. METHODS: The rate of metabolism of [(18)F]FDPN was mathematically quantified by fitting a bi-exponential function to each individual's dynamic metabolite data. RESULTS: No statistically significant gender differences were found for age, weight, body mass index or dose. However, significant differences (p < 0.01) in two of the four kinetic parameters describing the rate of metabolism were found between the two groups, with women metabolizing [(18)F]FDPN faster than men. These differences were found in the contribution of the fast and slow kinetic components of the model describing the distribution of radioactive species in plasma, indicating a higher rate of enzyme-dependent degradation of [(18)F]FDPN in women than in men. CONCLUSION: The findings reinforce the need for individualized metabolite correction during [(18)F]FDPN-PET scans and also indicate that in certain cases, grouping according to gender could be performed in order to minimize methodological errors of the input function prior to kinetic analyses.
Zeitschriftentitel:: Nuklearmedizin
Jahr:: 2006
Band / Volume:: 45
Heft / Issue:: 5
Seitenangaben Beitrag:: 197-200
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/17043729
Print-ISSN:: 0029-5566
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurologie (Prof. Hemmer)2006

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)2006