Selective imaging of the angiogenic relevant integrins ?5?1 and ?v?3.

Titel:: Selective imaging of the angiogenic relevant integrins ?5?1 and ?v?3.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Neubauer, S; Rechenmacher, F; Beer, AJ; Curnis, F; Pohle, K; D'Alessandria, C; Wester, HJ; Reuning, U; Corti, A; Schwaiger, M; Kessler, H
Abstract:: Pattern seekers: For the two angiogenic relevant integrins ?5?1 and ?v?3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first ?5?1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.
Zeitschriftentitel:: Angew Chem Int Ed Engl
Jahr:: 2013
Band / Volume:: 52
Heft / Issue:: 44
Seitenangaben Beitrag:: 11656-9
Sprache:: eng
Volltext / DOI:: doi:10.1002/anie.201306376
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/24115324
Print-ISSN:: 1433-7851
TUM Einrichtung:: Frauenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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