In a retrospective investigation 2 patient groups, who had been consecutively administered with the lysine analogues ε-aminocaproic acid (EACA) and tranexamic acid (TXA) as antifibrinolytic therapy during open heart surgery under cardiopulmonary bypass machine support, were compared. Following the use of TXA, a significant increase in new onset postoperative seizures became apparent. In contrast, the use of EACA was associated with a significant rise in new onset postoperative renal insufficiency. Regarding their impact on postoperative blood loss and transfusion requirements, both lysine analogues may be regarded as equivalent.
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In a retrospective investigation 2 patient groups, who had been consecutively administered with the lysine analogues ε-aminocaproic acid (EACA) and tranexamic acid (TXA) as antifibrinolytic therapy during open heart surgery under cardiopulmonary bypass machine support, were compared. Following the use of TXA, a significant increase in new onset postoperative seizures became apparent. In contrast, the use of EACA was associated with a significant rise in new onset postoperative renal insufficienc...
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