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Title:

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Author(s):
Schneiderhan, W; Scheler, M; Holzmann, KH; Marx, M; Gschwend, JE; Bucholz, M; Gress, TM; Seufferlein, T; Adler, G; Oswald, F
Abstract:
CD147 (basigin, EMMPRIN) is a multifunctional, highly conserved glycoprotein enriched in pancreatic ductal adenocarcinomas (PDACs) which is associated with poor prognosis in many malignancies. The role of CD147 in pancreatic cancer, however, remains elusive.Silencing of CD147 by RNA interference (RNAi) reduced the proliferation rate of MiaPaCa2 and Panc1 cells. CD147 is required for the function and expression of the monocarboxylate transporters MCT1 and MCT4 that are expressed in human PDAC cel...     »
Journal title abbreviation:
Gut
Year:
2009
Journal volume:
58
Journal issue:
10
Pages contribution:
1391-8
Language:
eng
Fulltext / DOI:
doi:10.1136/gut.2009.181412
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19505879
Print-ISSN:
0017-5749
TUM Institution:
Urologische Klinik und Poliklinik
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