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Title:

Role of T cells for cytokine production and outcome in a model of acute septic peritonitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Reim, D; Westenfelder, K; Kaiser-Moore, S; Schlautkötter, S; Holzmann, B; Weighardt, H
Abstract:
Although it is generally accepted that early defense mechanisms are controlled by cells of the innate immune system, T cells were found to be crucial for host resistance against acute septic peritonitis. However, the mechanisms by which T cells mediate protection are not fully understood. Here, we demonstrate mice deficient for recombinase-activating gene (RAG) 1, which lack mature B and T cells, showed enhanced susceptibility and impaired bacterial clearance in a model of acute septic peritonit...     »
Journal title abbreviation:
Shock
Year:
2009
Journal volume:
31
Journal issue:
3
Pages contribution:
245-50
Language:
eng
Fulltext / DOI:
doi:10.1097/SHK.0b013e31817fd02c
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18650777
Print-ISSN:
1073-2322
TUM Institution:
Chirurgische Klinik und Poliklinik; Urologische Klinik und Poliklinik
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