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Titel:

Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ceyhan, GO; Deucker, S; Demir, IE; Erkan, M; Schmelz, M; Bergmann, F; Müller, MW; Giese, T; Büchler, MW; Giese, NA; Friess, H
Abstract:
The chemokine fractalkine induces migration of inflammatory cells into inflamed tissues, thereby aggravating inflammatory tissue damage and fibrosis. Furthermore, fractalkine increases neuropathic pain through glial activation, which can be diminished by blocking of its receptor, CX3CR1, through neutralizing antibodies. As chronic pancreatitis (CP) is characterized by tissue infiltration of inflammatory cells, fibrosis, pancreatic neuritis and severe pain, the roles of fractalkine and CX3CR1 wer...     »
Zeitschriftentitel:
Lab Invest
Jahr:
2009
Band / Volume:
89
Heft / Issue:
3
Seitenangaben Beitrag:
347-61
Sprache:
eng
Volltext / DOI:
doi:10.1038/labinvest.2008.170
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19153557
Print-ISSN:
0023-6837
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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