New susceptibility locus for coronary artery disease on chromosome 3q22.3.

Erdmann, J; Grosshennig, A; Braund, PS; König, IR; Hengstenberg, C; Hall, AS; Linsel-Nitschke, P; Kathiresan, S; Wright, B; Trégouët, DA; Cambien, F; Bruse, P; Aherrahrou, Z; Wagner, AK; Stark, K; Schwartz, SM; Salomaa, V; Elosua, R; Melander, O; Voight, BF; O'Donnell, CJ; Peltonen, L; Siscovick, DS; Altshuler, D; Merlini, PA; Peyvandi, F; Bernardinelli, L; Ardissino, D; Schillert, A; Blankenberg, S; Zeller, T; Wild, P; Schwarz, DF; Tiret, L; Perret, C; Schreiber, S; El Mokhtari, NE; Schafer, A; März, W; Renner, W; Bugert, P; Klüter, H; Schrezenmeir, J; Rubin, D; Ball, SG; Balmforth, AJ; Wichmann, HE; Meitinger, T; Fischer, M; Meisinger, C; Baumert, J; Peters, A; Ouwehand, WH; Deloukas, P; Thompson, JR; Ziegler, A; Samani, NJ; Schunkert, H     «

Erdmann, J; Grosshennig, A; Braund, PS; König, IR; Hengstenberg, C; Hall, AS; Linsel-Nitschke, P; Kathiresan, S; Wright, B; Trégouët, DA; Cambien, F; Bruse, P; Aherrahrou, Z; Wagner, AK; Stark, K; Schwartz, SM; Salomaa, V; Elosua, R; Melander, O; Voight, BF; O'Donnell, CJ; Peltonen, L; Siscovick, DS; Altshuler, D; Merlini, PA; Peyvandi, F; Bernardinelli, L; Ardissino, D; Schillert, A; Blankenberg, S; Zeller, T; Wild, P; Schwarz, DF; Tiret, L; Perret, C; Schreiber, S; El Mokhtari, NE; Schafer, A;...     »

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).     «

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.0...     »