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Titel:

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Autor(en):
Willer, CJ; Speliotes, EK; Loos, RJ; Li, S; Lindgren, CM; Heid, IM; Berndt, SI; Elliott, AL; Jackson, AU; Lamina, C; Lettre, G; Lim, N; Lyon, HN; Mccarroll, SA; Papadakis, K; Qi, L; Randall, JC; Roccasecca, RM; Sanna, S; Scheet, P; Weedon, MN; Wheeler, E; Zhao, JH; Jacobs, LC; Prokopenko, I; Soranzo, N; Tanaka, T; Timpson, NJ; Almgren, P; Bennett, A; Bergman, RN; Bingham, SA; Bonnycastle, LL; Brown, M; Burtt, NP; Chines, P; Coin, L; Collins, FS; Connell, JM; Cooper, C; Smith, GD; Dennison, EM; D...     »
Abstract:
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Zeitschriftentitel:
Nat Genet
Jahr:
2009
Band / Volume:
41
Heft / Issue:
1
Seitenangaben Beitrag:
25-34
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.287
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19079261
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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