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Title:

Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fritsche, LG; Freitag-Wolf, S; Bettecken, T; Meitinger, T; Keilhauer, CN; Krawczak, M; Weber, BH
Abstract:
Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In this study, we have defined an extended haplotype block encompassing the entire APOE gene locus, includ...     »
Journal title abbreviation:
Hum Mutat
Year:
2009
Journal volume:
30
Journal issue:
7
Pages contribution:
1048-53
Language:
eng
Fulltext / DOI:
doi:10.1002/humu.20957
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19384966
Print-ISSN:
1059-7794
TUM Institution:
Institut für Humangenetik
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