Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer, CJ; Speliotes, EK; Loos, RJ; Li, S; Lindgren, CM; Heid, IM; Berndt, SI; Elliott, AL; Jackson, AU; Lamina, C; Lettre, G; Lim, N; Lyon, HN; Mccarroll, SA; Papadakis, K; Qi, L; Randall, JC; Roccasecca, RM; Sanna, S; Scheet, P; Weedon, MN; Wheeler, E; Zhao, JH; Jacobs, LC; Prokopenko, I; Soranzo, N; Tanaka, T; Timpson, NJ; Almgren, P; Bennett, A; Bergman, RN; Bingham, SA; Bonnycastle, LL; Brown, M; Burtt, NP; Chines, P; Coin, L; Collins, FS; Connell, JM; Cooper, C; Smith, GD; Dennison, EM; Deodhar, P; Elliott, P; Erdos, MR; Estrada, K; Evans, DM; Gianniny, L; Gieger, C; Gillson, CJ; Guiducci, C; Hackett, R; Hadley, D; Hall, AS; Havulinna, AS; Hebebrand, J; Hofman, A; Isomaa, B; Jacobs, KB; Johnson, T; Jousilahti, P; Jovanovic, Z; Khaw, KT; Kraft, P; Kuokkanen, M; Kuusisto, J; Laitinen, J; Lakatta, EG; Luan, J; Luben, RN; Mangino, M; McArdle, WL; Meitinger, T; Mulas, A; Munroe, PB; Narisu, N; Ness, AR; Northstone, K; O'Rahilly, S; Purmann, C; Rees, MG; Ridderstråle, M; Ring, SM; Rivadeneira, F; Ruokonen, A; Sandhu, MS; Saramies, J; Scott, LJ; Scuteri, A; Silander, K; Sims, MA; Song, K; Stephens, J; Stevens, S; Stringham, HM; Tung, YC; Valle, TT; van Duijn, CM; Vimaleswaran, KS; Vollenweider, P; Waeber, G; Wallace, C; Watanabe, RM; Waterworth, DM; Watkins, N; Witteman, JC; Zeggini, E; Zhai, G; Zillikens, MC; Altshuler, D; Caulfield, MJ; Chanock, SJ; Farooqi, IS; Ferrucci, L; Guralnik, JM; Hattersley, AT; Hu, FB; Jarvelin, MR; Laakso, M; Mooser, V; Ong, KK; Ouwehand, WH; Salomaa, V; Samani, NJ; Spector, TD; Tuomi, T; Tuomilehto, J; Uda, M; Uitterlinden, AG; Wareham, NJ; Deloukas, P; Frayling, TM; Groop, LC; Hayes, RB; Hunter, DJ; Mohlke, KL; Peltonen, L; Schlessinger, D; Strachan, DP; Wichmann, HE; McCarthy, MI; Boehnke, M; Barroso, I; Abecasis, GR; Hirschhorn, JN

doi:10.1038/ng.287

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2009

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Document type:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Author(s):: Willer, CJ; Speliotes, EK; Loos, RJ; Li, S; Lindgren, CM; Heid, IM; Berndt, SI; Elliott, AL; Jackson, AU; Lamina, C; Lettre, G; Lim, N; Lyon, HN; Mccarroll, SA; Papadakis, K; Qi, L; Randall, JC; Roccasecca, RM; Sanna, S; Scheet, P; Weedon, MN; Wheeler, E; Zhao, JH; Jacobs, LC; Prokopenko, I; Soranzo, N; Tanaka, T; Timpson, NJ; Almgren, P; Bennett, A; Bergman, RN; Bingham, SA; Bonnycastle, LL; Brown, M; Burtt, NP; Chines, P; Coin, L; Collins, FS; Connell, JM; Cooper, C; Smith, GD; Dennison, EM; Deodhar, P; Elliott, P; Erdos, MR; Estrada, K; Evans, DM; Gianniny, L; Gieger, C; Gillson, CJ; Guiducci, C; Hackett, R; Hadley, D; Hall, AS; Havulinna, AS; Hebebrand, J; Hofman, A; Isomaa, B; Jacobs, KB; Johnson, T; Jousilahti, P; Jovanovic, Z; Khaw, KT; Kraft, P; Kuokkanen, M; Kuusisto, J; Laitinen, J; Lakatta, EG; Luan, J; Luben, RN; Mangino, M; McArdle, WL; Meitinger, T; Mulas, A; Munroe, PB; Narisu, N; Ness, AR; Northstone, K; O'Rahilly, S; Purmann, C; Rees, MG; Ridderstråle, M; Ring, SM; Rivadeneira, F; Ruokonen, A; Sandhu, MS; Saramies, J; Scott, LJ; Scuteri, A; Silander, K; Sims, MA; Song, K; Stephens, J; Stevens, S; Stringham, HM; Tung, YC; Valle, TT; van Duijn, CM; Vimaleswaran, KS; Vollenweider, P; Waeber, G; Wallace, C; Watanabe, RM; Waterworth, DM; Watkins, N; Witteman, JC; Zeggini, E; Zhai, G; Zillikens, MC; Altshuler, D; Caulfield, MJ; Chanock, SJ; Farooqi, IS; Ferrucci, L; Guralnik, JM; Hattersley, AT; Hu, FB; Jarvelin, MR; Laakso, M; Mooser, V; Ong, KK; Ouwehand, WH; Salomaa, V; Samani, NJ; Spector, TD; Tuomi, T; Tuomilehto, J; Uda, M; Uitterlinden, AG; Wareham, NJ; Deloukas, P; Frayling, TM; Groop, LC; Hayes, RB; Hunter, DJ; Mohlke, KL; Peltonen, L; Schlessinger, D; Strachan, DP; Wichmann, HE; McCarthy, MI; Boehnke, M; Barroso, I; Abecasis, GR; Hirschhorn, JN «
Willer, CJ; Speliotes, EK; Loos, RJ; Li, S; Lindgren, CM; Heid, IM; Berndt, SI; Elliott, AL; Jackson, AU; Lamina, C; Lettre, G; Lim, N; Lyon, HN; Mccarroll, SA; Papadakis, K; Qi, L; Randall, JC; Roccasecca, RM; Sanna, S; Scheet, P; Weedon, MN; Wheeler, E; Zhao, JH; Jacobs, LC; Prokopenko, I; Soranzo, N; Tanaka, T; Timpson, NJ; Almgren, P; Bennett, A; Bergman, RN; Bingham, SA; Bonnycastle, LL; Brown, M; Burtt, NP; Chines, P; Coin, L; Collins, FS; Connell, JM; Cooper, C; Smith, GD; Dennison, EM; D... »
Title:: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Abstract:: Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Journal title abbreviation:: Nat Genet
Year:: 2009
Journal volume:: 41
Journal issue:: 1
Pages contribution:: 25-34
Language:: eng
Fulltext / DOI:: doi:10.1038/ng.287
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19079261
Print-ISSN:: 1061-4036
TUM Institution:: Institut für Humangenetik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Humangenetik (Prof. Winkelmann)2009

mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Institut für Humangenetik