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Title:

Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men.

Document type:
Journal Article
Author(s):
Wu, L; Luthringer, B J C; Feyerabend, F; Zhang, Z; Machens, H G; Maeda, M; Taipaleenmäki, H; Hesse, E; Willumeit-Römer, R; Schilling, A F
Abstract:
To better understand the association between high salt intake and osteoporosis, we investigated the effect of sodium chloride (NaCl) on mice and human osteoclastogenesis. The results suggest a direct, activating role of NaCl supplementation on bone resorption.High NaCl intake is associated with increased urinary calcium elimination and parathyroid hormone (PTH) secretion which in turn stimulates the release of calcium from the bone, resulting in increased bone resorption. However, while calciuri...     »
Journal title abbreviation:
Osteoporos Int
Year:
2017
Journal volume:
28
Journal issue:
11
Pages contribution:
3215-3228
Language:
eng
Fulltext / DOI:
doi:10.1007/s00198-017-4163-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28849275
Print-ISSN:
0937-941X
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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