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Title:

DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Scumaci, Domenica; Olivo, Erika; Fiumara, Claudia Vincenza; La Chimia, Marina; De Angelis, Maria Teresa; Mauro, Sabrina; Costa, Giosuè; Ambrosio, Francesca Alessandra; Alcaro, Stefano; Agosti, Valter; Costanzo, Francesco Saverio; Cuda, Giovanni
Abstract:
Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high glycolytic flux induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl species makes DNA, proteins, and lipids more susceptible to glycation. Together with glucose, methylglyoxal (MGO), a byproduct of glycolysis, is considered the main glycating agent. MGO is highly diffusible, enters the nucleus, and can react with easily accessible lysine- and arginine-rich tails of histones. Glycati...     »
Journal title abbreviation:
Cells
Year:
2020
Journal volume:
9
Journal issue:
9
Fulltext / DOI:
doi:10.3390/cells9091968
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32858971
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin
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