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Titel:

CD201+ fascia progenitors choreograph injury repair.

Dokumenttyp:
Journal Article
Autor(en):
Correa-Gallegos, Donovan; Ye, Haifeng; Dasgupta, Bikram; Sardogan, Aydan; Kadri, Safwen; Kandi, Ravinder; Dai, Ruoxuan; Lin, Yue; Kopplin, Robert; Shenai, Disha Shantaram; Wannemacher, Juliane; Ichijo, Ryo; Jiang, Dongsheng; Strunz, Maximilian; Ansari, Meshal; Angelidis, Illias; Schiller, Herbert B; Volz, Thomas; Machens, Hans-Günther; Rinkevich, Yuval
Abstract:
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating...     »
Zeitschriftentitel:
Nature
Jahr:
2023
Band / Volume:
623
Heft / Issue:
7988
Seitenangaben Beitrag:
792-802
Volltext / DOI:
doi:10.1038/s41586-023-06725-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37968392
Print-ISSN:
0028-0836
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann); Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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