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Titel:

Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men.

Dokumenttyp:
Journal Article
Autor(en):
Wu, L; Luthringer, B J C; Feyerabend, F; Zhang, Z; Machens, H G; Maeda, M; Taipaleenmäki, H; Hesse, E; Willumeit-Römer, R; Schilling, A F
Abstract:
To better understand the association between high salt intake and osteoporosis, we investigated the effect of sodium chloride (NaCl) on mice and human osteoclastogenesis. The results suggest a direct, activating role of NaCl supplementation on bone resorption.High NaCl intake is associated with increased urinary calcium elimination and parathyroid hormone (PTH) secretion which in turn stimulates the release of calcium from the bone, resulting in increased bone resorption. However, while calciuri...     »
Zeitschriftentitel:
Osteoporos Int
Jahr:
2017
Band / Volume:
28
Heft / Issue:
11
Seitenangaben Beitrag:
3215-3228
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00198-017-4163-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28849275
Print-ISSN:
0937-941X
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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